THE INTO-HLH REGISTRY
BUILDING ACOMMUNITY OF HOPE
INTO-HLH Registry is a collaboration between Cincinnati Children's Hospital Medical Center (CCHMC), Texas Children's Hospital (TCH), the North American Consortium of Histiocytosis (NACHO), and Sobi North America as the industry sponsor.
Hemophagocytic lymphohistiocytosis (HLH) is a hyperinflammatory syndrome resulting in life-threatening organ damage.
The causes of Hemophagocytic Lymphohistiocytosis (HLH) are not always clear, but most often, it occurs either due to inborn problems of immune regulation or as a complication of rheumatologic conditions or cancers. It may be triggered by infections in each of these contexts.
HLH is characterized by a unique set of clinical and laboratory features such as low blood counts, very elevated markers of inflammation, and an increase in the size of the spleen. This distinctive condition occurs in different clinical contexts, where it may appear and be treated somewhat differently.
SPOTLIGHT ON RESEARCH
Understanding of HLH continues to grow and inform therapy: recent findings and ideas
Here we highlight a few recent papers of specific scientific or clinical interest related to HLH and related disorders. In the future, as data in the INTO-HLH Registry leads to new publications, we will also highlight these specifically.