Serum proteome analysis of systemic JIA and related lung disease identifies distinct inflammatory programs and biomarkers. Chen G, Deutsch GH, Schulert G, et al. Arthritis Rheumatol. 2022;10.1002/art.42099. doi:10.1002/art.42099

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Systemic onset Juvenile Idiopathic Arthritis (sJIA), macrophage activation syndrome (MAS), and pulmonary alveolar proteinosis (PAP)-like disease in the context of sJIA are syndromes with common features. Chen et al. conducted a SOMAscan proteomic analysis of >1300 analytes in sera of these patients, suggesting that these diseases represent an inflammatory continuum and provided biomarkers to distinguish between them.