THE INTO-HLH REGISTRY
BUILDING A COMMUNITY OF HOPE
INTO-HLH (Insight into the Natural History and Treatment Outcomes of Hemophagocytic Lymphohistiocytosis) is a disease Registry aimed at advancing what is known about HLH. The insights obtained from this Registry will help doctors to better diagnose and manage HLH and improve treatment outcomes for future patients.
INTO-HLH Registry is a collaboration between Cincinnati Children's Hospital Medical Center (CCHMC), Texas Children's Hospital (TCH), and Sobi North America as the industry sponsor.
HLH Overview
Hemophagocytic lymphohistiocytosis (HLH) is a hyperinflammatory syndrome resulting in life-threatening organ damage.
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The causes of Hemophagocytic Lymphohistiocytosis (HLH) are not always clear, but most often, it occurs either due to inborn problems of immune regulation or as a complication of rheumatologic conditions or cancers. It may be triggered by infections in each of these contexts.
HLH is characterized by a unique set of clinical and laboratory features such as low blood counts, very elevated markers of inflammation, and an increase in the size of the spleen. This distinctive condition occurs in different clinical contexts, where it may appear and be treated somewhat differently.
SPOTLIGHT ON RESEARCH
Understanding of HLH continues to grow and inform therapy: recent findings and ideas
Here we highlight a few recent papers of specific scientific or clinical interest related to HLH and related disorders. In the future, as data in the INTO-HLH Registry leads to new publications, we will also highlight these specifically.